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Article

A critical role for the cytoplasmic tail of pTalpha in T lymphocyte development.

Nature immunology - 1 May 2002

Aifantis Iannis, Borowski Christine, Gounari Fotini, Lacorazza H Daniel, Nikolich-Zugich Janko, von Boehmer Harald

Abstract excerpt

Signals that emanate from the pre-T cell receptor (pre-TCR) regulate multiple processes required for the development of the alphabeta T cell lineage. In contrast to the gammadelta TCR, the pre-TCR localizes cell-autonomously to membrane rafts, where it appears to signal in a constitutive and ligand-independent manner. We addressed here the role played by structural features specific to the cytoplasmic domain of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Receptors, Antigen, T-Cell, alpha-beta

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Source

Identifiers

PMID: 11927911
DOI: 10.1038/ni779

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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