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Article

A role for a PDZ protein in the early secretory pathway for the targeting of proTGF-alpha to the cell surface.

Molecular cell - 1 Apr 1999

Fernández-Larrea J, Merlos-Suárez A, Ureña J M, Baselga J, Arribas J

Abstract excerpt

In general, plasma membrane integral proteins, such as the membrane-anchored growth factor proTGF-alpha, are assumed to be transported to the cell surface via a nonregulated, constitutive pathway. proTGF-alpha C-terminal mutants are retained in an early secretory compartment. Here, using a two-hybrid screen, we identify two TACIPs (proTGF-alpha cytoplasmic domain-interacting proteins) that contain PDZ domains and...

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PMID: 10230395
DOI: 10.1016/s1097-2765(00)80470-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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