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Article

Fas/CD95 prevents autoimmunity independently of lipid raft localization and efficient apoptosis induction.

Nature communications - 23 Dec 2016

Cruz Anthony C, Ramaswamy Madhu, Ouyang Claudia, Klebanoff Christopher A, Sengupta Prabuddha, Yamamoto Tori N, Meylan Françoise, Thomas Stacy K, Richoz Nathan, Eil Robert, Price Susan, Casellas Rafael, Rao V Koneti, Lippincott-Schwartz Jennifer, Restifo Nicholas P, Siegel Richard M

Abstract excerpt

Mutations affecting the apoptosis-inducing function of the Fas/CD95 TNF-family receptor result in autoimmune and lymphoproliferative disease. However, Fas can also costimulate T-cell activation and promote tumour cell growth and metastasis. Palmitoylation at a membrane proximal cysteine residue enables Fas to localize to lipid raft microdomains and induce apoptosis in cell lines. Here, we show that a...

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Identifiers

PMID: 28008916
DOI: 10.1038/ncomms13895
PMCID: PMC5196435

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TNF

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