The T-cell-receptor signaling network

Abstract excerpt

T-cell-receptor (TCR) signaling in response to antigen recognition has a central role in the adaptive immune response. Furthermore, the comprehensive nature of the TCR signaling network is such that it has become a model system for complex cellular responses ranging from gene regulation to cytoskeletal remodeling. Over the past five years, our understanding of TCR signaling has evolved on a number of fronts....

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