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Article

Phospholipase Cγ1 is required for pre-TCR signal transduction and pre-T cell development.

European journal of immunology - 1 Jan 2017

Fu Guoping, Yu Mei, Chen Yuhong, Zheng Yongwei, Zhu Wen, Newman Debra K, Wang Demin, Wen Renren

Abstract excerpt

Pre-T cell receptor (TCR) signaling is required for pre-T cell survival, proliferation, and differentiation from the CD4 and CD8 double negative (DN) to the double positive (DP) stage. However, the pre-TCR signal transduction pathway is not fully understood and the signaling molecules involved have not been completely identified. Phospholipase Cγ (PLCγ) 1 is an important signaling molecule that generates two...

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Identifiers

PMID: 27759161
DOI: 10.1002/eji.201646522
PMCID: PMC5559087

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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