Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Brc1-mediated rescue of Smc5/6 deficiency: requirement for multiple nucleases and a novel Rad18 function.

Genetics - 1 Apr 2007

Lee Karen M, Nizza Suzanne, Hayes Thomas, Bass Kirstin L, Irmisch Anja, Murray Johanne M, O'Connell Matthew J

Abstract excerpt

Smc5/6 is a structural maintenance of chromosomes complex, related to the cohesin and condensin complexes. Recent studies implicate Smc5/6 as being essential for homologous recombination. Each gene is essential, but hypomorphic alleles are defective in the repair of a diverse array of lesions. A particular allele of smc6 (smc6-74) is suppressed by overexpression of Brc1, a six-BRCT domain protein that is required...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle Proteins
Share to Chromosomal Proteins, Non-Histone

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA-(Apurinic or Apyrimidinic Site) Lyase

Share to DNA, Fungal

Share to Exodeoxyribonucleases

Share to Genes, Fungal

Share to Schizosaccharomyces

Share to Schizosaccharomyces pombe Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 17277362
DOI: 10.1534/genetics.106.067801
PMCID: PMC1855136

Genes

PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Brc1-mediated rescue of Smc5/6 deficiency: requirement for multiple nucleases and a novel Rad18 function.PMID 17277362Read ↗

Identification of a novel non-structural maintenance of chromosomes (SMC) component of the SMC5-SMC6 complex involved in DNA repair.Semantic proximity Read ↗

SMC5 and SMC6 genes are required for the segregation of repetitive chromosome regions.Semantic proximity Read ↗

Rad62 protein functionally and physically associates with the smc5/smc6 protein complex and is required for chromosome integrity and recombination repair in fission yeast.Semantic proximity Read ↗

Smc5/6 Is a Telomere-Associated Complex that Regulates Sir4 Binding and TPE.Semantic proximity Read ↗

Coordination of DNA damage responses via the Smc5/Smc6 complex.Semantic proximity Read ↗

The Saccharomyces cerevisiae Esc2 and Smc5-6 proteins promote sister chromatid junction-mediated intra-S repair.Semantic proximity Read ↗

The Nse5-Nse6 dimer mediates DNA repair roles of the Smc5-Smc6 complex.Semantic proximity Read ↗

Smc5/6 is required for repair at collapsed replication forks.Semantic proximity Read ↗

Novel essential DNA repair proteins Nse1 and Nse2 are subunits of the fission yeast Smc5-Smc6 complex.Semantic proximity Read ↗

SMC6 is an essential gene in mice, but a hypomorphic mutant in the ATPase domain has a mild phenotype with a range of subtle abnormalities.Semantic proximity Read ↗

Smc5/6 maintains stalled replication forks in a recombination-competent conformation.Semantic proximity Read ↗

The Smc5/6 complex is required for dissolution of DNA-mediated sister chromatid linkages.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.