Article
Isoniazid pharmacokinetics in children according to acetylator phenotype.
Fundamental & clinical pharmacology - 1 Oct 2001
Rey E, Gendrel D, Treluyer J M, Tran A, Pariente-Khayat A, d'Athis P, Pons G
Abstract excerpt
The pharmacokinetics of isoniazid (INH) was studied in children (0-196 months old) according to their acetylator phenotype, estimated from the metabolic acetyl INH/INH molar plasma concentration ratio (MR) measured 3 h after INH oral administration. There were 17 slow (MR < 0.48) and 17 fast acetylators (MR > or = 0.48). The mean apparent plasma clearance was significantly lower, the mean apparent volume of...
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