Article
N-acetylation phenotyping with sulphadimidine in a Turkish population.
European journal of clinical pharmacology - 1 Jan 1990
Bozkurt A, Basci N E, Kalan S, Tuncer M, Kayaalp S O
Abstract excerpt
The distribution of acetylator phenotypes was studied in 244 unrelated Turkish subjects. Sulphadimidine and its acetylated metabolite were measured in 6 h plasma and 0-6 h urine samples after an oral dose of 10 mg/kg. Subjects with 37.5% or less acetylsulphadimidine in plasma were regarded as slow acetylators and the others as rapid acetylators. The mean plasma concentration of acetylsulphadimidine was about...
Topics
- Acetylation
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Female
- Humans
- Male
- Middle Aged
- Phenotype
- Sulfamethazine
- Time Factors