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Article

Determination of the acetylator phenotype in Moroccan tuberculosis patients using isoniazid as metabolic probe.

International journal of clinical pharmacology and therapeutics - 1 Dec 2002

Aït Moussa L, Khassouani C E, Hüe B, Jana M, Bégaud B, Soulaymani R

Abstract excerpt

A large interindividual variability in drug acetylation is associated with genetic polymorphism of the polymorphic Type 2 N-acetyltransferase (NAT2), and an important interethnic difference has been frequently observed. However, few data on this polymorphism in the Moroccan population are available. In the present study the acetylator phenotype in 89 Moroccan patients with tuberculosis has been determined using...

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Topics

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Share to Acetylation
Share to Adolescent

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Antitubercular Agents

Share to Arylamine N-Acetyltransferase

Share to Isoniazid

Share to Metabolic Clearance Rate

Share to Polymorphism, Genetic

Share to Tuberculosis, Pulmonary

Source

Identifiers

PMID: 12503812
DOI: 10.5414/cpp40548

Genes

NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Determination of the acetylator phenotype in Moroccan tuberculosis patients using isoniazid as metabolic probe.PMID 12503812Read ↗

Distribution of allelic and genotypic frequencies of NAT2 and CYP2E1 variants in Moroccan population.Semantic proximity Read ↗

A study of N-acetyltransferase 2 gene polymorphisms in the Indian population and its relationship with serum isoniazid concentrations in a cohort of tuberculosis patients.Semantic proximity Read ↗

Determination of N-acetylation phenotyping in a Greek population using caffeine as a metabolic probe.Semantic proximity Read ↗

Arylamine N-acetyltransferase acetylation polymorphisms: paradigm for pharmacogenomic-guided therapy- a focused review.Semantic proximity Read ↗

Correlation of N-acetyltransferase 2 genotype with isoniazid acetylation in Polish tuberculosis patients.Semantic proximity Read ↗

NAT2 Genotypes in Moroccan Patients with Hepatotoxicity Due to Antituberculosis Drugs.Semantic proximity Read ↗

N-acetyltransferase gene polymorphisms & plasma isoniazid concentrations in patients with tuberculosis.Semantic proximity Read ↗

Age-distribution and genotype-phenotype correlation for N-acetyltransferase in Argentine children under isoniazid treatment.Semantic proximity Read ↗

Study of NAT2 gene polymorphisms in an Indian population: association with plasma isoniazid concentration in a cohort of tuberculosis patients.Semantic proximity Read ↗

Full-gene-sequencing analysis of N-acetyltransferase-2 in an adult Indian population.Semantic proximity Read ↗

Expression of NAT2 in immune system cells and the relation of NAT2 gene polymorphisms in the anti-tuberculosis therapy in Mexican mestizo population.Semantic proximity Read ↗

Correlation of N-acetyltransferase 2 genotype and acetylation status with plasma isoniazid concentration and its metabolic ratio in ethiopian tuberculosis patients.Semantic proximity Read ↗

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