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Article

N-acetylation of drugs. Pharmacogenetic studies in rabbits selected for their acetylator characteristics.

Drug metabolism and disposition: the biological fate of chemicals - 1 Jan 2000

Weber W W, Miceli J N, Hearse D J, Drummond G S

Abstract excerpt

Studies on acetylation of sulfadiazine, isoniazid, and p-aminobenzoic acid in selected lines of slow and rapid acetylator rabbits are described. Pedigree analysis of rabbits classified as slow or rapid sulfadiazine acetylators confirmed previous studies that the rate of sulfadiazine elimination (acetylation) is genetically controlled, with rapid elimination dominant over slow elimination of the drug....

Topics

Acetyltransferases
Aminobenzoates
Animals
Female
Kinetics
Male
Phenotype
Rabbits
Sulfadiazine

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 3408

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-3408-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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