Article
[Pharmacokinetics of procainamide and its metabolite depending on acetylator phenotype].
Polski tygodnik lekarski (Warsaw, Poland : 1960) - 1 Jan 2000
Gawrońska-Szklarz B, Górnik W, Kutrzeba J, Wójcicki J, Zakrzewski J
Abstract excerpt
Procainamide (Pa) and its active metabolite--N-acetylprocainamide (NAPA)--pharmacokinetics was studied in 12 healthy volunteers in relation to acetylation phenotype. Acetylation phenotype was determined with sulphadimidine test. Blood serum levels of PA and NAPA were determined 0.5; 1.0; 1.5; 2.0; 3.0; 4.0; 8.0; and 12 hours following a single oral dose of 500 mg. Blood levels of both PA and NAPA were assayed...
Topics
- Acecainide
- Acetylation
- Adult
- Female
- Humans
- Male
- Phenotype
- Procainamide
- Reference Values