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Article

Isoniazid pharmacokinetics in children treated for respiratory tuberculosis.

Archives of disease in childhood - 1 Jun 2005

Schaaf H S, Parkin D P, Seifart H I, Werely C J, Hesseling P B, van Helden P D, Maritz J S, Donald P R

Abstract excerpt

AIMS: To define the pharmacokinetics of isoniazid (INH) in children with tuberculosis in relation to the N-acetyltransferase 2 (NAT2) genotype. METHODS: The first order elimination rate constant (k) and area under the concentration curve (AUC) were calculated in 64 children <13 years of age (median 3.8) with respiratory tuberculosis from INH concentrations determined 2-5 hours after a 10 mg/kg INH dose. The NAT2...

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Identifiers

PMID: 15908628
DOI: 10.1136/adc.2004.052175
PMCID: PMC1720436

Genes

NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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