Article
Classification of children as slow or rapid acetylators based on concentrations of isoniazid in saliva following oral administration of body-weight and surface-area-related dosages of the drug.
Indian pediatrics - 1 Feb 1990
Sarma G R, Kailasam S, Datta M, Loganathan G K, Rahman F, Narayana A S
Abstract excerpt
The acetylator phenotype of 180 children aged 3-11 years was determined on the basis of isoniazid concentrations in saliva collected at 5 hours after oral administration of body-weight and surface-area-related dosages of the drug in a syrup form. Isoniazid 2.5 mg/kg was administered on one occasi...
Topics
- Acetylation
- Acetyltransferases
- Administration, Oral
- Body Surface Area
- Body Weight
- Child
- Child, Preschool
- Dose-Response Relationship, Drug
- Humans
- Isoniazid
- Phenotype
- Saliva