Isoniazid acetylation metabolic ratio during maturation in children.

doi:10.1016/S0009-9236(97)90115-6

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Article

Isoniazid acetylation metabolic ratio during maturation in children.

Clinical pharmacology and therapeutics - 1 Oct 1997

Pariente-Khayat A, Rey E, Gendrel D, Vauzelle-Kervroëdan F, Crémier O, d'Athis P, Badoual J, Olive G, Pons G

Abstract excerpt

Isoniazid acetylation metabolic ratio (MR) was studied in 61 children with tuberculosis after administration of isoniazid. MR was calculated as the molar acetylisoniazid to isoniazid concentration ratio. MR was used as a probe for N-acetyltransferase activity and to determine the acetylation phen...

Topics

Acetylation
Adolescent
Aging
Antitubercular Agents
Arylamine N-Acetyltransferase
Child
Child, Preschool
Humans
Infant
Infant, Newborn
Isoniazid
Phenotype
Retrospective Studies

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