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Article

Isoniazid acetylation metabolic ratio during maturation in children.

Clinical pharmacology and therapeutics - 1 Oct 1997

Pariente-Khayat A, Rey E, Gendrel D, Vauzelle-Kervroëdan F, Crémier O, d'Athis P, Badoual J, Olive G, Pons G

Abstract excerpt

Isoniazid acetylation metabolic ratio (MR) was studied in 61 children with tuberculosis after administration of isoniazid. MR was calculated as the molar acetylisoniazid to isoniazid concentration ratio. MR was used as a probe for N-acetyltransferase activity and to determine the acetylation phenotype. MR had a bimodal distribution with an antimode between 0.48 and 0.77. MR and the percentage of fast acetylators...

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Identifiers

PMID: 9357388
DOI: 10.1016/S0009-9236(97)90115-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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