Article
Multiple mutations are common at mouse Aprt in genotoxin-exposed mismatch repair deficient cells.
Oncogene - 7 Mar 2002
Shin Chi Y, Mellon Isabel, Turker Mitchell S
Abstract excerpt
Mismatch repair deficiency is known to contribute to elevated rates of mutations, particularly at mono- and dinucleotide repeat sequences. However, such repeats are often missing from the coding regions of endogenous genes. To determine the types of mutations that can occur within an endogenous gene lacking highly susceptible repeat sequences, we examined mutagenic events at the 2.3 kb mouse Aprt gene in kidney...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.