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Article

Differing patterns of genetic instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6.

Carcinogenesis - 1 Dec 2006

Hegan Denise Campisi, Narayanan Latha, Jirik Frank R, Edelmann Winfried, Liskay R Michael, Glazer Peter M

Abstract excerpt

Defects in genes associated with DNA mismatch repair (MMR) have been linked to hereditary colon cancer. Because the MMR pathway includes multiple factors with both overlapping and divergent functions, we sought to compare the impact of deficiencies in each of several MMR genes on genetic instability using a collection of knock-out mouse models. We investigated mutation frequencies and patterns in MMR-deficient...

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Identifiers

PMID: 16728433
DOI: 10.1093/carcin/bgl079
PMCID: PMC2612936

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Source receipt: pubmed, retrieved 7 Sept 2026.

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