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Article

Frequency and types of spontaneous Hprt lymphocyte mutations in Pms2-deficient mice.

Mutation research - 20 Mar 2006

Shaddock Joseph G, Dobrovolsky Vasily N, Mittelstaedt Roberta A, Heflich Robert H, Parsons Barbara L

Abstract excerpt

Deficiencies in DNA mismatch repair (MMR) result in predisposition to neoplasia in both rodents and humans. Pms2 is one of the several proteins involved in the eukaryotic MMR system. In order to determine the effect of Pms2-deficiency on mutation, we measured mutant frequencies in the endogenous Hprt gene of lymphocytes from male Pms2(-/-), Pms2(+/-), and Pms2(+/+) mice. Spleens were removed from mice of various...

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Identifiers

PMID: 16336979
DOI: 10.1016/j.mrfmmm.2005.10.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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