Article
A novel signature mutation for oxidative damage resembles a mutational pattern found commonly in human cancers.
Cancer research - 15 Apr 1999
Turker M S, Gage B M, Rose J A, Elroy D, Ponomareva O N, Stambrook P J, Tischfield J A
Abstract excerpt
To determine the types of mutations induced by oxidative damage, a kidney cell line with a heterozygous deficiency for the autosomal Aprt (adenine phosphoribosyltransferase) gene was tested for its mutagenic response to hydrogen peroxide. Aprt-deficient cells were selected and scored for loss of heterozygosity (LOH) for 11 microsatellite loci on mouse chromosome 8. On the basis of the LOH analysis, spontaneous...
Topics
- Adenine Phosphoribosyltransferase
- Animals
- Cells, Cultured
- Chromosomes, Human, Pair 8
- DNA Damage
- Female
- Humans
- Hydrogen Peroxide
- Kidney
- Loss of Heterozygosity
- Male
- Mice
- Mice, Inbred C57BL
- Mutation
- Neoplasms
- Oxidative Stress