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Article

A novel signature mutation for oxidative damage resembles a mutational pattern found commonly in human cancers.

Cancer research - 15 Apr 1999

Turker M S, Gage B M, Rose J A, Elroy D, Ponomareva O N, Stambrook P J, Tischfield J A

Abstract excerpt

To determine the types of mutations induced by oxidative damage, a kidney cell line with a heterozygous deficiency for the autosomal Aprt (adenine phosphoribosyltransferase) gene was tested for its mutagenic response to hydrogen peroxide. Aprt-deficient cells were selected and scored for loss of heterozygosity (LOH) for 11 microsatellite loci on mouse chromosome 8. On the basis of the LOH analysis, spontaneous...

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PMID: 10213488

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A novel signature mutation for oxidative damage resembles a mutational pattern found commonly in human cancers.PMID 10213488Read ↗

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