Article
Elevated levels of mutation in multiple tissues of mice deficient in the DNA mismatch repair gene Pms2.
Proceedings of the National Academy of Sciences of the United States of America - 1 Apr 1997
Narayanan L, Fritzell J A, Baker S M, Liskay R M, Glazer P M
Abstract excerpt
The Pms2 gene has been implicated in hereditary colon cancer and is one of several mammalian homologs of the Escherichia coli mutL DNA mismatch repair gene. To determine the effect of Pms2 inactivation on genomic integrity in vivo, hybrid transgenic mice were constructed that carry targeted disruptions at the Pms2 loci along with a chromosomally integrated mutation reporter gene. In the absence of any mutagenic...
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