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Article

Carcinogen-induced loss of heterozygosity at the Aprt locus in somatic cells of the mouse.

Proceedings of the National Academy of Sciences of the United States of America - 10 Nov 1998

Wijnhoven S W, Van Sloun P P, Kool H J, Weeda G, Slater R, Lohman P H, van Zeeland A A, Vrieling H

Abstract excerpt

Genetic events leading to the loss of heterozygosity (LOH) have been shown to play a crucial role in the development of cancer. However, LOH events do not occur only in genetically unstable cancer cells but also have been detected in normal somatic cells of mouse and man. Mice, in which one of the alleles for adenine phosphoribosyltransferase (Aprt) has been disrupted by gene targeting, were used to investigate...

Topics

9,10-Dimethyl-1,2-benzanthracene
Adenine Phosphoribosyltransferase
Alleles
Animals
Carcinogens
Female
Humans
Loss of Heterozygosity
Male
Mice
Neoplasms

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Identifiers

PMID: 9811874
DOI: 10.1073/pnas.95.23.13759
PMCID: PMC24893

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