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Article

Mutagenesis in PMS2- and MSH2-deficient mice indicates differential protection from transversions and frameshifts.

Carcinogenesis - 1 Jul 2000

Andrew S E, Xu X S, Baross-Francis A, Narayanan L, Milhausen K, Liskay R M, Jirik F R, Glazer P M

Abstract excerpt

DNA mismatch repair (MMR) deficiency leads to an increased mutation frequency and a predisposition to neoplasia. 'Knockout' mice deficient in the MMR proteins Msh2 and Pms2 crossed with mutation detection reporter (supF, lacI and cII) transgenic mice have been used to facilitate a comparison of t...

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Source

Identifiers

PMID: 10874005

Genes

MSH2
PMS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-10874005-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Mutagenesis in PMS2- and MSH2-deficient mice indicates differential protection from transversions and frameshifts.PMID 10874005Read ↗

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