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Article

Different mutator phenotypes in Mlh1- versus Pms2-deficient mice.

Proceedings of the National Academy of Sciences of the United States of America - 8 Jun 1999

Yao X, Buermeyer A B, Narayanan L, Tran D, Baker S M, Prolla T A, Glazer P M, Liskay R M, Arnheim N

Abstract excerpt

Deficiencies in DNA mismatch repair (MMR) result in increased mutation rates and cancer risk in both humans and mice. Mouse strains homozygous for knockouts of either the Pms2 or Mlh1 MMR gene develop cancer but exhibit very different tumor spectra; only Mlh1(-/-) animals develop intestinal tumors. We carried out a detailed study of the microsatellite mutation spectra in each knockout strain. Five mononucleotide...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 10359802
DOI: 10.1073/pnas.96.12.6850
PMCID: PMC22005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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