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Article

Role of the mismatch repair gene, Msh6, in suppressing genome instability and radiation-induced mutations.

Mutation research - 3 Jul 2008

Barrera-Oro Julio, Liu Tzu-Yang, Gorden Erin, Kucherlapati Raju, Shao Changshun, Tischfield Jay A

Abstract excerpt

Mismatch repair (MMR) is critical for preserving genomic integrity. Failure of this system can accelerate somatic mutation and increase the risk of developing cancer. MSH6, in complex with MSH2, is the MMR protein that mediates DNA repair through the recognition of 1- and 2-bp mismatches. To eval...

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Source

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Identifiers

PMID: 18538799
DOI: 10.1016/j.mrfmmm.2008.04.006
PMCID: PMC2476210

Genes

MSH6
APRT
MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-18538799-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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