Article
Loss of heterozygosity in primary lung cancer using laser capture microdissection and WAVE DNA fragment analysis techniques.
Medical science monitor : international medical journal of experimental and clinical research - 1 Mar 2002
Zhu Weigang, Zou Helen, Beck Amy, Chervinsky Dave, Malik Debbie, Brooks John, Tan Dongfeng
Abstract excerpt
BACKGROUND: A number of molecular changes observed by varied conventional methods, including loss of heterozygosity (LOH) on chromosome 3, have been associated with primary lung cancer. To further define the locus of chromosome 3p allele loss in lung cancer, we performed LOH study by using innovative laser capture microdissection and WAVE DNA Fragment Analysis. MATERIAL/METHODS: Thirty-eight paired specimens from...
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