PCR-based RFLP analysis allows genotyping of the short arm of chromosome 3 in small biopsies from patients with lung cancer.

doi:10.1016/0888-7543(92)90369-4

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Article

PCR-based RFLP analysis allows genotyping of the short arm of chromosome 3 in small biopsies from patients with lung cancer.

Genomics - 1 Feb 1992

Ganly P S, Jarad N, Rudd R M, Rabbitts P H

Abstract excerpt

The tumors of patients with lung cancers often show loss of heterozygosity (LOH) at polymorphic loci on the short arm of chromosome 3. Most examples of small-cell lung carcinoma (SCLC) cannot be examined since they are infrequently resected. Small biopsies are, however, usually available from pat...

Topics

Alleles
Base Sequence
Chromosomes, Human, Pair 3
DNA Probes
DNA, Neoplasm
Genotype
Heterozygote
Humans
Lung Neoplasms
Molecular Sequence Data
Polydeoxyribonucleotides
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length

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