Article
High-throughput loss-of-heterozygosity study of chromosome 3p in lung cancer using single-nucleotide polymorphism markers.
Cancer research - 15 Apr 2006
Tai Amy L S, Mak William, Ng Phoebe K M, Chua Daniel T T, Ng Mandy Y M, Fu Li, Chu Kevin K W, Fang Yan, Qiang Song You, Chen Muhan, Zhang Minyue, Sham Pak C, Guan Xin-Yuan
Abstract excerpt
Loss of DNA copy number at the short arm of chromosome 3 is one of the most common genetic changes in human lung cancer, suggesting the existence of one or more tumor suppressor genes (TSG) at 3p. To identify most frequently deleted regions and candidate TSGs within these regions, a recently developed single-nucleotide polymorphism (SNP)-mass spectrometry-genotyping (SMSG) technology was applied to investigate...
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