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Article

Loss of heterozygosity of chromosome 3p markers in small-cell lung cancer.

Nature - 1 Jan 2000

Naylor S L, Johnson B E, Minna J D, Sakaguchi A Y

Abstract excerpt

Specific chromosomal deletions sometimes associated with tumours such as retinoblastoma (chromosome 13q14) and Wilm's tumour (chromosome 11p13) have led to the hypothesis that recessive genes may be involved in tumorigenesis. This hypothesis is supported by demonstration of allele loss specific for these regions using polymorphic DNA markers and by the isolation of a complementary DNA clone for the retinoblastoma...

Topics

Alleles
Carcinoma, Small Cell
Cell Line
Chromosome Aberrations
Chromosome Deletion
Chromosomes, Human, Pair 3
DNA, Neoplasm
Heterozygote
Humans
Karyotyping
Lung Neoplasms
Nucleic Acid Hybridization

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Genetic

Source

Identifiers

PMID: 2821400
DOI: 10.1038/329451a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2821400-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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