Article
High resolution chromosome 3p allelotyping of human lung cancer and preneoplastic/preinvasive bronchial epithelium reveals multiple, discontinuous sites of 3p allele loss and three regions of frequent breakpoints.
Cancer research - 1 Apr 2000
Wistuba I I, Behrens C, Virmani A K, Mele G, Milchgrub S, Girard L, Fondon J W, Garner H R, McKay B, Latif F, Lerman M I, Lam S, Gazdar A F, Minna J D
Abstract excerpt
Allele loss involving chromosome arm 3p is one of the most frequent and earliest known genetic events in lung cancer pathogenesis and may affect several potential tumor suppressor gene regions. To further study the role of chromosome 3p allele loss in the pathogenesis of lung cancer, we performed high resolution loss of heterozygosity (LOH) studies on 97 lung cancer and 54 preneoplastic/preinvasive microdissected...
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