Allele-specific chromosome 3p deletions occur at an early stage in the pathogenesis of lung carcinoma.

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Article

Allele-specific chromosome 3p deletions occur at an early stage in the pathogenesis of lung carcinoma.

JAMA - 15 Feb 1995

Hung J, Kishimoto Y, Sugio K, Virmani A, McIntire D D, Minna J D, Gazdar A F

Abstract excerpt

BACKGROUND: Deletions in the short arm of chromosome 3 (3p) are present in most lung carcinomas. OBJECTIVE: To investigate the role of these chromosome 3p deletions in the pathogenesis of non-small cell lung carcinomas. DESIGN: Seven archival, paraffin-embedded, surgically resected lung cancer specimens were studied. Fifty precisely identified malignant and preneoplastic lesions present in bronchi, bronchioles,...

Topics

Aged
Aged, 80 and over
Alleles
Base Sequence
Carcinoma, Non-Small-Cell Lung
Cell Transformation, Neoplastic
Chromosome Deletion
Chromosomes, Human, Pair 3
DNA
Female
Heterozygote

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Hyperplasia

Lung

Lung Neoplasms

Male

Middle Aged

Molecular Sequence Data

Source

Open in PubMed

Identifiers

PMID: 7837389

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7837389-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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