Article
Molecular mapping of deletion sites in the short arm of chromosome 3 in human lung cancer.
Genes, chromosomes & cancer - 1 Jan 1990
Brauch H, Tory K, Kotler F, Gazdar A F, Pettengill O S, Johnson B, Graziano S, Winton T, Buys C H, Sorenson G D
Abstract excerpt
We used 10 restriction fragment length polymorphism (RFLP) probes spanning the length of the short arm of chromosome 3 (3p) to map deletion sites in human lung cancer. Two approaches were used. 1) When a patient's tumor and normal tissue were available, loci with allelic heterozygosity in the nor...
Topics
- Alleles
- Carcinoma, Non-Small-Cell Lung
- Carcinoma, Small Cell
- Chromosome Deletion
- Chromosomes, Human, Pair 3
- DNA Probes
- Genetic Markers
- Heterozygote
- Humans
- Lung Neoplasms
- Polymorphism, Restriction Fragment Length
- Tumor Cells, Cultured