Article
Molecular mapping of deletion sites in the short arm of chromosome 3 in human lung cancer.
Genes, chromosomes & cancer - 1 Jan 1990
Brauch H, Tory K, Kotler F, Gazdar A F, Pettengill O S, Johnson B, Graziano S, Winton T, Buys C H, Sorenson G D
Abstract excerpt
We used 10 restriction fragment length polymorphism (RFLP) probes spanning the length of the short arm of chromosome 3 (3p) to map deletion sites in human lung cancer. Two approaches were used. 1) When a patient's tumor and normal tissue were available, loci with allelic heterozygosity in the normal tissue were tested for loss of alleles at 3p. 2) When the corresponding normal tissue was not available, the...
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