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Article

dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1.

Nature cell biology - 1 Mar 2002

Radimerski Thomas, Montagne Jacques, Rintelen Felix, Stocker Hugo, van der Kaay Jeroen, Downes C Peter, Hafen Ernst, Thomas George

Abstract excerpt

Genetic studies in Drosophila melanogaster underscore the importance of the insulin-signalling pathway in controlling cell, organ and animal size. Effectors of this pathway include Chico (the insulin receptor substrate homologue), dPI(3)K, dPKB, dPTEN, and dS6K. Mutations in any of these components have a striking effect on cell size and number, with the exception of dS6K. Mutants in dS6K affect cell size but not...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 11862217
DOI: 10.1038/ncb763

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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