Article
Essential role of PDK1 in regulating cell size and development in mice.
The EMBO journal - 15 Jul 2002
Lawlor Margaret A, Mora Alfonso, Ashby Peter R, Williams Michayla R, Murray-Tait Victoria, Malone Lorraine, Prescott Alan R, Lucocq John M, Alessi Dario R
Abstract excerpt
PDK1 functions as a master kinase, phosphorylating and activating PKB/Akt, S6K and RSK. To learn more about the roles of PDK1, we generated mice that either lack PDK1 or possess PDK1 hypomorphic alleles, expressing only approximately 10% of the normal level of PDK1. PDK1(-/-) embryos die at embryonic day 9.5, displaying multiple abnormalities including lack of somites, forebrain and neural crest derived tissues;...
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