Article

Syd/JIP3 Controls Tissue Size by Regulating Diap1 Protein Turnover Downstream of Yorkie/YAP

2020-04-20

Abstract excerpt

How organisms control organ size is not fully understood. We found that Syd/JIP3 is required for proper wing size in Drosophila . JIP3 mutations are associated with organ size defects in mammals. The underlying mechanisms are not well understood. We discovered that Syd/JIP3 inhibition results in a downregulation of the inhibitor of apoptosis protein1 (Diap1) in the Drosophila wing. Correspondingly, Syd/JIP3 def...

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Literature Corpus work: b09c3fb7-5a45-5047-9d9f-816bdea06dc8
DOI: 10.1101/2020.04.19.049023

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