Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB.

Nature cell biology - 1 Dec 1999

Verdu J, Buratovich M A, Wilder E L, Birnbaum M J

Abstract excerpt

Organismal size is determined by a tightly regulated mechanism that coordinates cell growth, cell proliferation and cell death. The Drosophila insulin receptor/Chico/Dp110 pathway regulates cell and organismal size. Here we show that genetic manipulation of the phosphoinositide-3-OH-kinase-depend...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Count
Share to Cell Size
Share to Eye

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phosphoinositide-3 Kinase Inhibitors

Share to Proto-Oncogene Proteins c-akt

Share to Receptor, Insulin

Share to Transformation, Genetic

Share to Wings, Animal

Source

Identifiers

PMID: 10587646
DOI: 10.1038/70293

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-10587646-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB.PMID 10587646Read ↗

Do growth and cell division rates determine cell size in multicellular organisms?Semantic proximity Read ↗

dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1.Semantic proximity Read ↗

Compensatory growth in novel Drosophila Akt1 mutants.Semantic proximity Read ↗

Akt is negatively regulated by Hippo signaling for growth inhibition in Drosophila.Semantic proximity Read ↗

The<i>Drosophila</i>insulin/IGF receptor controls growth and size by modulating PtdIns<i>P</i>3 levelsSemantic proximity Read ↗

Insulin receptor-mediated signaling via phospholipase C-γ regulates growth and differentiation in Drosophila.Semantic proximity Read ↗

Essential role of PDK1 in regulating cell size and development in mice.Semantic proximity Read ↗

The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling.Semantic proximity Read ↗

Regulation of cell growth by autophagySemantic proximity Read ↗

The temporal requirements for insulin signaling during development in Drosophila.Semantic proximity Read ↗

Syd/JIP3 Controls Tissue Size by Regulating Diap1 Protein Turnover Downstream of Yorkie/YAPSemantic proximity Read ↗

Akt/protein kinase B promotes organ growth in transgenic mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.