The<i>Drosophila</i>insulin/IGF receptor controls growth and size by modulating PtdIns<i>P</i>3 levels

Abstract excerpt

Understanding the control of size is of fundamental biological and clinical importance. Insulin/IGF signaling during development controls growth and size, possibly by coordinating the activities of the Ras and PI 3-kinase signaling pathways. We show that in Drosophila mutating the consensus binding site for the Ras pathway adaptor Drk/Grb2 in Chico/IRS does not interfere with growth whereas mutating the binding...

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