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Article

The Drosophila insulin-degrading enzyme restricts growth by modulating the PI3K pathway in a cell-autonomous manner.

Molecular biology of the cell - 1 Mar 2014

Galagovsky Diego, Katz Maximiliano J, Acevedo Julieta M, Sorianello Eleonora, Glavic Alvaro, Wappner Pablo

Abstract excerpt

Mammalian insulin-degrading enzyme (IDE) cleaves insulin, among other peptidic substrates, but its function in insulin signaling is elusive. We use the Drosophila system to define the function of IDE in the regulation of growth and metabolism. We find that either loss or gain of function of Drosophila IDE (dIDE) can restrict growth in a cell-autonomous manner by affecting both cell size and cell number. dIDE can...

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Identifiers

PMID: 24430872
DOI: 10.1091/mbc.E13-04-0213
PMCID: PMC3952859

Genes

IDE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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