Article
A fat body-derived IGF-like peptide regulates postfeeding growth in Drosophila.
Developmental cell - 1 Dec 2009
Okamoto Naoki, Yamanaka Naoki, Yagi Yoshimasa, Nishida Yasuyoshi, Kataoka Hiroshi, O'Connor Michael B, Mizoguchi Akira
Abstract excerpt
Members of the insulin family of peptides have conserved roles in the regulation of growth and metabolism in a wide variety of metazoans. Here we show that Drosophila insulin-like peptide 6 (DILP6), which is structurally similar to vertebrate insulin-like growth factor (IGF), is predominantly expressed in the fat body, a functional equivalent of the vertebrate liver and adipocytes. This expression occurs during...
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