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Article

The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling.

Journal of biology - 1 Jan 2003

Jünger Martin A, Rintelen Felix, Stocker Hugo, Wasserman Jonathan D, Végh Mátyás, Radimerski Thomas, Greenberg Michael E, Hafen Ernst

Abstract excerpt

BACKGROUND: Forkhead transcription factors belonging to the FOXO subfamily are negatively regulated by protein kinase B (PKB) in response to signaling by insulin and insulin-like growth factor in Caenorhabditis elegans and mammals. In Drosophila, the insulin-signaling pathway regulates the size of cells, organs, and the entire body in response to nutrient availability, by controlling both cell size and cell...

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Identifiers

PMID: 12908874
DOI: 10.1186/1475-4924-2-20
PMCID: PMC333403

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling.PMID 12908874Read ↗

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dFOXO-independent effects of reduced insulin-like signaling in Drosophila.Semantic proximity Read ↗

Caenorhabditis elegans DAF-16/FOXO transcription factor and its mammalian homologs associate with age-related diseaseSemantic proximity Read ↗

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Caenorhabditis elegans EAK-3 inhibits dauer arrest via nonautonomous regulation of nuclear DAF-16/FoxO activity.Semantic proximity Read ↗

Activated FOXO-mediated insulin resistance is blocked by reduction of TOR activity.Semantic proximity Read ↗

JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling.Semantic proximity Read ↗

The Drosophila FoxA ortholog Fork head regulates growth and gene expression downstream of Target of rapamycin.Semantic proximity Read ↗

FOXO-regulated transcription restricts overgrowth of Tsc mutant organs.Semantic proximity Read ↗

FOXO regulates organ-specific phenotypic plasticity in Drosophila.Semantic proximity Read ↗

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