Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling.

Journal of biology - 1 Jan 2003

Jünger Martin A, Rintelen Felix, Stocker Hugo, Wasserman Jonathan D, Végh Mátyás, Radimerski Thomas, Greenberg Michael E, Hafen Ernst

Abstract excerpt

BACKGROUND: Forkhead transcription factors belonging to the FOXO subfamily are negatively regulated by protein kinase B (PKB) in response to signaling by insulin and insulin-like growth factor in Caenorhabditis elegans and mammals. In Drosophila, the insulin-signaling pathway regulates the size o...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3-Phosphoinositide-Dependent Protein Kinases
Share to Caenorhabditis elegans Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Death

Share to Energy Intake

Share to Forkhead Transcription Factors

Share to Genes, Insect

Share to Insulin Receptor Substrate Proteins

Share to Organ Size

Source

Open in PubMed Open full text

Identifiers

PMID: 12908874
DOI: 10.1186/1475-4924-2-20
PMCID: PMC333403

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12908874-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling.PMID 12908874Read ↗

Expression of Drosophila FOXO regulates growth and can phenocopy starvation.Semantic proximity Read ↗

Understanding Forkhead Box Class O Function: Lessons from <i>Drosophila melanogaster</i>Semantic proximity Read ↗

dFOXO-independent effects of reduced insulin-like signaling in Drosophila.Semantic proximity Read ↗

Caenorhabditis elegans DAF-16/FOXO transcription factor and its mammalian homologs associate with age-related diseaseSemantic proximity Read ↗

The Drosophila insulin-degrading enzyme restricts growth by modulating the PI3K pathway in a cell-autonomous manner.Semantic proximity Read ↗

Caenorhabditis elegans EAK-3 inhibits dauer arrest via nonautonomous regulation of nuclear DAF-16/FoxO activity.Semantic proximity Read ↗

Activated FOXO-mediated insulin resistance is blocked by reduction of TOR activity.Semantic proximity Read ↗

JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling.Semantic proximity Read ↗

The Drosophila FoxA ortholog Fork head regulates growth and gene expression downstream of Target of rapamycin.Semantic proximity Read ↗

FOXO-regulated transcription restricts overgrowth of Tsc mutant organs.Semantic proximity Read ↗

FOXO regulates organ-specific phenotypic plasticity in Drosophila.Semantic proximity Read ↗

FOXO3 and Related Transcription Factors in Development, Aging, and Exceptional LongevitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.