Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Drosophila SH2B family adaptor Lnk acts in parallel to chico in the insulin signaling pathway.

PLoS genetics - 1 Aug 2009

Werz Christian, Köhler Katja, Hafen Ernst, Stocker Hugo

Abstract excerpt

Insulin/insulin-like growth factor signaling (IIS) plays a pivotal role in the regulation of growth at the cellular and the organismal level during animal development. Flies with impaired IIS are developmentally delayed and small due to fewer and smaller cells. In the search for new growth-promoting genes, we identified mutations in the gene encoding Lnk, the single fly member of the SH2B family of adaptor...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Body Size
Share to Insulin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Insulin Receptor Substrate Proteins

Share to Intracellular Signaling Peptides and Proteins

Share to Multigene Family

Share to Receptor, Insulin

Share to src Homology Domains

Source

Open in PubMed Open full text

Identifiers

PMID: 19680438
DOI: 10.1371/journal.pgen.1000596
PMCID: PMC2716533

Genes

PIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Drosophila SH2B family adaptor Lnk acts in parallel to chico in the insulin signaling pathway.PMID 19680438Read ↗

Regulation of lifespan, metabolism, and stress responses by the Drosophila SH2B protein, Lnk.Semantic proximity Read ↗

dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1.Semantic proximity Read ↗

High Sugar-Induced Insulin Resistance in Drosophila Relies on the Lipocalin Neural LazarilloSemantic proximity Read ↗

The<i>Drosophila</i>insulin/IGF receptor controls growth and size by modulating PtdIns<i>P</i>3 levelsSemantic proximity Read ↗

Insulin receptor-mediated signaling via phospholipase C-γ regulates growth and differentiation in Drosophila.Semantic proximity Read ↗

Two membrane-associated tyrosine phosphatase homologs potentiate C. elegans AKT-1/PKB signaling.Semantic proximity Read ↗

Drosophila Longevity Assurance Conferred by Reduced Insulin Receptor Substrate Chico Partially Requires d4eBP.Semantic proximity Read ↗

The cytohesin Steppke is essential for insulin signalling in Drosophila.Semantic proximity Read ↗

Mutations in the Drosophila insulin receptor substrate, CHICO, impair olfactory associative learning.Semantic proximity Read ↗

PDP-1 links the TGF-β and IIS pathways to regulate longevity, development, and metabolism.Semantic proximity Read ↗

Insulin receptor substrate chico acts with the transcription factor FOXO to extend Drosophila lifespan.Semantic proximity Read ↗

The regulation of circadian rhythm by insulin signaling in <i>Drosophila</i>Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.