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Article

The cytohesin Steppke is essential for insulin signalling in Drosophila.

Nature - 14 Dec 2006

Fuss Bernhard, Becker Thomas, Zinke Ingo, Hoch Michael

Abstract excerpt

In metazoans, the insulin signalling pathway has a key function in regulating energy metabolism and organismal growth. Its activation stimulates a highly conserved downstream kinase cascade that includes phosphatidylinositol-3-OH kinase (PI(3)K) and the serine-threonine protein kinase Akt. This study identifies a new component of insulin signalling in Drosophila, the steppke gene (step). step encodes a member of...

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PMID: 17167488
DOI: 10.1038/nature05412

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The cytohesin Steppke is essential for insulin signalling in Drosophila.PMID 17167488Read ↗

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Guanine nucleotide exchange factors of the cytohesin family and their roles in signal transductionSemantic proximity Read ↗

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