Article
Haplotype frequency estimation in patient populations: the effect of departures from Hardy-Weinberg proportions and collapsing over a locus in the HLA region.
Genetic epidemiology - 1 Feb 2002
Single Richard M, Meyer Diogo, Hollenbach Jill A, Nelson Mark P, Noble Janelle A, Erlich Henry A, Thomson Glenys
Abstract excerpt
Haplotype analyses are an important area in the study of the genetic components of human disease. Associations between markers and disease loci that are not evident with a single marker locus may be identified in multi-locus marker analyses using estimated haplotype frequencies (HFs). Procedures that make use of the expectation-maximization (EM) algorithm to estimate HFs from unphased genotype data are in common...
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