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Article

Haplotype frequency estimation error analysis in the presence of missing genotype data.

BMC bioinformatics - 1 Dec 2004

Kelly Enda D, Sievers Fabian, McManus Ross

Abstract excerpt

BACKGROUND: Increasingly researchers are turning to the use of haplotype analysis as a tool in population studies, the investigation of linkage disequilibrium, and candidate gene analysis. When the phase of the data is unknown, computational methods, in particular those employing the Expectation-Maximisation (EM) algorithm, are frequently used for estimating the phase and frequency of the underlying haplotypes....

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Identifiers

PMID: 15574202
DOI: 10.1186/1471-2105-5-188
PMCID: PMC544188

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