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Article

Penalized estimation of haplotype frequencies.

Bioinformatics (Oxford, England) - 15 Jul 2008

Ayers Kristin L, Lange Kenneth

Abstract excerpt

MOTIVATION: Low haplotype diversity and linkage disequilibrium are the rule in short genomic segments. This fact suggests that parsimony should be enforced in estimation of haplotype frequencies. The current article introduces a diversity penalty that automatically discards potential haplotypes with low explanatory power. The standard EM algorithm for haplotype frequency estimation can accommodate the penalty if...

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Identifiers

PMID: 18487240
DOI: 10.1093/bioinformatics/btn236

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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