Article
Inference on haplotype effects in case-control studies using unphased genotype data.
American journal of human genetics - 1 Dec 2003
Epstein Michael P, Satten Glen A
Abstract excerpt
A variety of statistical methods exist for detecting haplotype-disease association through use of genetic data from a case-control study. Since such data often consist of unphased genotypes (resulting in haplotype ambiguity), such statistical methods typically apply the expectation-maximization (EM) algorithm for inference. However, the majority of these methods fail to perform inference on the effect of...
Topics
- Algorithms
- Case-Control Studies
- Diabetes Mellitus, Type 2
- Genetic Predisposition to Disease
- Haplotypes
- Humans
- Likelihood Functions
- Models, Genetic
- Polymorphism, Single Nucleotide
- Risk Factors