Incorporating genotyping uncertainty in haplotype frequency estimation in pedigree studies.

Abstract excerpt

AIMS: Haplotype frequency estimation is indispensable in studies of human genetics based on haplotypes since studies based on haplotypes are likely to yield more information than those based on single SNP marker. However, most existing algorithms estimate haplotype frequencies under the assumption that all of the genotype data sets are correct. To date, nearly all large genotype data sets have errors, and studies...

Topics

• Algorithms
• Gene Frequency
• Genotype
• Haplotypes
• Humans
• Likelihood Functions
• Pedigree