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Article

HLA haplotype frequency estimation for heterogeneous populations using a graph-based imputation algorithm.

Human immunology - 1 Oct 2021

Israeli Sapir, Gragert Loren, Maiers Martin, Louzoun Yoram

Abstract excerpt

HLA haplotype frequencies are estimated from ambiguous unphased HLA genotyping data using Expectation-Maximization (EM) algorithms. Current population genetics methods require independent EM frequency estimates for each population, and assume that each population is in Hardy-Weinberg Equilibrium (HWE). The HWE assumption of EM has thus far resulted in the exclusion of individuals from mixed or unknown ethnic...

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Identifiers

PMID: 34325951
DOI: 10.1016/j.humimm.2021.07.001

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