Article
Estimating haplotype frequencies and standard errors for multiple single nucleotide polymorphisms.
Biostatistics (Oxford, England) - 1 Oct 2003
Li Shuying Sue, Khalid Najma, Carlson Christopher, Zhao Lue Ping
Abstract excerpt
Estimating haplotype frequencies becomes increasingly important in the mapping of complex disease genes, as millions of single nucleotide polymorphisms (SNPs) are being identified and genotyped. When genotypes at multiple SNP loci are gathered from unrelated individuals, haplotype frequencies can...
Topics
- Algorithms
- Alleles
- Analysis of Variance
- Computational Biology
- Computer Simulation
- Gene Frequency
- Genotype
- Haplotypes
- Humans
- Likelihood Functions
- Models, Genetic
- Polymorphism, Single Nucleotide
- Sensitivity and Specificity