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Article

Estimating HLA haplotype frequencies from homozygous individuals - A Technical Report.

International journal of immunogenetics - 1 Dec 2021

Seitz Susanne, Lange Vinzenz, Norman Paul J, Sauter Jürgen, Schmidt Alexander H

Abstract excerpt

We estimated HLA haplotype frequencies based on individuals homozygous for 4, 5 or 6 loci. Validation of our approach using a sample of over 3.4 million German individuals was successful. Compared to an expectation-maximization algorithm, the errors were larger. However, our approach allows the unequivocal detection of rare haplotypes.

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Identifiers

PMID: 34570965
DOI: 10.1111/iji.12553
PMCID: PMC9131737

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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