Article
Analysis of the role of MKK-4/Sek-1 in T cell development and apoptosis.
International immunology - 1 Aug 1998
Alberola-Ila J, Levin S D, Barton G, Forbush K, Zon L I, Perlmutter R M
Abstract excerpt
The stress-activated protein kinases (SAPK) are a group of dual-specificity kinases with potential roles in the control of apoptosis and proliferation. In most cells they are regulated through phosphorylation by MKK-4. We have investigated the role of MKK-4 in T cell development and function by g...
Topics
- Animals
- Antibodies, Monoclonal
- Antigens, CD
- Apoptosis
- Calcium-Calmodulin-Dependent Protein Kinases
- Catalytic Domain
- Enzyme Activation
- Flow Cytometry
- Ionomycin
- JNK Mitogen-Activated Protein Kinases
- MAP Kinase Kinase 4
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Mitogen-Activated Protein Kinase Kinases
- Mitogen-Activated Protein Kinases
- Mutation
- Precipitin Tests