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Article

Analysis of the role of MKK-4/Sek-1 in T cell development and apoptosis.

International immunology - 1 Aug 1998

Alberola-Ila J, Levin S D, Barton G, Forbush K, Zon L I, Perlmutter R M

Abstract excerpt

The stress-activated protein kinases (SAPK) are a group of dual-specificity kinases with potential roles in the control of apoptosis and proliferation. In most cells they are regulated through phosphorylation by MKK-4. We have investigated the role of MKK-4 in T cell development and function by generating transgenic animals expressing catalytically inactive MKK-4 (dMKK-4) in the thymus. Our results show that...

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Identifiers

PMID: 9723693
DOI: 10.1093/intimm/10.8.1077

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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