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Article

Stimulation of naive CD8+ T cells by a variant viral epitope induces activation and enhanced apoptosis.

Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 2010

Ream Rebecca M, Sun Jie, Braciale Thomas J

Abstract excerpt

Classically, naive T cells recognize a specific peptide-MHC complex resulting in their activation and differentiation. However, it is known that T cells also have the ability to interact productively with variant ligands, indicating a flexibility in TCR Ag recognition. These altered peptide ligands have been shown to trigger responses ranging from complete activation to full inhibition of T cell responses, and...

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Identifiers

PMID: 20139280
DOI: 10.4049/jimmunol.0902448
PMCID: PMC2996134

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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